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Tie Chong

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图片4.jpgPERSONAL INFORMATION

Name: Tie Chong, MD, Ph.D.

Gender: male Date of birth: 08/25/1967

Chief physician/ professor

Department of Urology,

The Second Affiliated Hospital of Xi’an Jiaotong University,

Xi’an, Shaanxi, China

E-mail: chongtie@126.com

EDUCATION

5/2005-10/2005Visiting scholar: Midlands Centre for Spinal Injuries, Robert Jones and Agnes Hunts Orthopaedic Hospital; Belgium Antwerp University; and Austria Innsbruck University

9/2001-7/2007Doctor degree in Surgery, School of Medicine, Xi’an Jiaotong University, Xi’an, China

9/1992-7/1995Master Degree in Surgery, School of Medicine, Xi’an Jiaotong University, Xi’an, China

9/1985-7/1990Bachelor Degree in Clinical Medicine, School of Medicine, Xi’an Jiaotong University, Xi’an, China

PROFESSIONAL EXPERIENCES

3/2018-presentChief physician, Professor, Chief of the Department of Urology, Chief of the Department of Surgery, Department of Urology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

09/2011-2/2018Chief physician, Professor, Chief of the Department of Urology, Department of Urology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

12/2006-8/2011Chief physician, Deputy chief of the Department of Urology, Department of Urology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

6/2001-11/2006Deputy chief physician, Department of Urology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

6/1996-5/2001Attending physician, Department of Urology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

7/1990-5/1996Resident physician, Department of Urology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

MEMBERSHIP

1. Standing Committee member of Urology Branch of Chinese Medical Association

2. Standing Committee member of Urology Branch of Chinese Medical Doctor Association

3. Chairman Committee member of Urology Branch of Shaanxi province Medical Association

PUBLICATION (first or corresponding author)

Effect of dual mTOR inhibitor on TGFβ1-induced fibrosis in primary human urethral scar fibroblastsBiomedicine & Pharmacotherapy2018:1182-1187
Inhibition of Recombining Binding Protein Suppressor of Hairless (RBPJ) Impairs the Growth of Prostate CancerCell Physiol Biochem2015;36(5):1982-90
Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancerJ Drug Target2020 Jan;28(1):41-45
Dynamic changes of different phenotypic and genetic circulating tumor cells as a biomarker for evaluating the prognosis of RCCCancer biology & therapy2019;20(4):505-12
Dendritic cells serve as a "Trojan horse" for oncolytic adenovirus delivery in the treatment of mouse prostate cancerActa Pharmacol Sin2016 Aug;37(8):1121-8
Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancerBiological research2020 Oct 16
Kinesin Motor Protein KIFC1 Is a Target Protein of miR-338-3p and Is Associated With Poor Prognosis and Progression of Renal Cell CarcinomaOncology research2018;27(1):125-37
The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinomaBMC CANCERDEC 7 2020
Genistein attenuates di(2ethylhexyl) phthalate-induced testicular injuries via activation of Nrf2/HO1 following prepubertal exposureInt J Mol Med2018;41(3):1437-1446
Downregulation of microRNA-15a suppresses the proliferation and invasion of renal cell carcinoma via direct targeting of eIF4EOncol Rep2017 Oct; 38(4): 1995–2002
Identification of angiogenesis-related miRNAs in a population of patients with renal clear cell carcinomaOncol Rep2014 Nov;32(5):2061-9
Identification of key genes and functions of circulating tumor cells in multiple cancers through bioinformaticBMC Medical Genomics2020 Sep 24;13(1):140
The Effect of Stone Composition on the Efficacy of Retrograde Intrarenal Surgery: Kidney Stones 1-3 cm in DiameterJ Endourol2015 May;29(5):537-41
Screening disrupted molecular functions and pathways associated with clear cell renal cell carcinoma using Gibbs samplingComput Biol Chem2017 Oct; 70:15-20
Clinical application of drug sensitive gene detection in postoperative instillation for non-muscle invasive bladder cancerBMC NEPHROLOGY.OCT 7 2020
TUG1 knockdown inhibits the tumorigenesis and progression of prostate cancer by regulating microRNA-496/Wnt/β-catenin pathwayAnticancer Drugs2020 Jul;31(6):592-600
Association of ATG7 Polymorphisms and Clear Cell Renal Cell Carcinoma RiskCurrent molecular medicine2019 Feb 27
The Significance of Detection of Circulating Tumor Cells and Beclin1 in Peripheral Blood of Patients with Renal Cell CarcinomaCrit Rev Eukaryot Gene Expr2020;30(6):483-492
Rapamycin inhibits formation of urethral stricture in rabbitsJournal of Pharmacology and Experimental Therapeutics2011,338(1):47-52
Rapamycin inhibts the growth and collagen production of fibroblase derived from human urehtral scar tissueBiomed Research International2018(13):1-8
TPX2 in human clear cell renal carcinoma: Expression, function and prognostic significanceOncol Lett2016 May;11(5):3515-3521
EZH2 enhances the invasive capability of renal cell carcinoma cells via activation of STAT3Mol Med Rep2018, 17(3): 3621-3626
A novel anti‑cancer effect of resveratrol: reversal of epithelial‑mesenchymal transition in prostate cancer cellsMol Med Rep2014 Oct;10(4):1717-24
Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinomaEXPERIMENTAL AND THERAPEUTIC MEDICINEJUL 2016
Anuria and abdominal pain induced by ceftriaxone-associated ureterolithiasis in adultsInt Urol Nephrol2013 Feb;45(1):73-6
Bioinformatic screening and identification of downregulated hub genes in adrenocortical carcinomaExp Ther Med2020 Sep;20(3):2730-2742
Knockdown of prostaglandin reductase 1 (PTGR1) suppresses prostate cancer cell proliferation by inducing cell cycle arrest and apoptosisBiosci Trends2016 May 23;10(2):133-9
Retroperitoneal laparoscopic partial nephrectomy versus radical nephrectomy for clinical t1 renal hilar tumor: comparison of perioperative characteristics and short-term functional and oncologic outcomesJournal of Laparoendoscopic & Advanced Surgical Techniques Part A2018
Transurethral resection in women with symptomatic keratinizing squamous metaplasia of urinary bladder: A retrospective study of 92 casesLow Urin Tract Symptoms2019
The impact of TNFSF14 on prognosis and immune microenvironment in clear cell re-nal cell carcinomaGenes Genomics2020 Jul 28
Low-energy shock wave preconditioning reduces renal ischemic reperfusion injury caused by renal artery occlusionActa Cir Bras2017 Jul;32(7):550-558
RBPJ contributes to acquired docetaxel resistance in prostate cancer cellsMolecular & Cellular Toxicology 2017 , 13 (3) :279-285

ADVANTAGE

Our team specializes in the diagnosis and treatment of urinary tumors as well as urinary benign diseases, especially the application and promotion of endoscopic and laparoscopic techniques.

GRANTS (PI: Tie Chong)

1. National Nature Science Foundation of China, 82070716, Study of MSCs exosomes inhibiting urethral fibrosis based on Smads/let-7/TGFβR1 signal axis regulating extracellular matrix remodeling, 2021/01-2024/12, CNY550,000

2. National Nature Science Foundation of China,81770689, Role of mTOR signal pathway in urethral stricture formation and screening of key therapeutic targets,2018/01-2021/12,CNY520,000

3. National Nature Science Foundation of China,30972977, Construction and screening of immunotoxin attenuated Stx1A-anti G250 and experimental study on its antitumor effect and mechanism on renal cell carcinoma,2010/01-2012/12,CNY260,000

4. Natural Science major Research Project of Shaanxi Province, 2016ZDJC-12, Translational medicine study of antifibrotic drugs inhibiting urethral stricture formation, 2016/01-2018/12, CNY300,000

TEACHING ACTIVITIES

2005-present: surgery for medical students, Xi’an Jiaotong University

HONORS AND AWARDS

Science and Technology Progress Award of Shaanxi Province (2021, 2005, 1999):

1. Establishment and application of key technologies for precision diagnosis and treatment of renal cancer;

2. Study on the clinical significance of prostate specific antigen in prostate cancer diagnosis;

3. Study on the mechanisms and biological behaviors of multiple gene products and renal cancer.


executive editor: