Na Liu

CURRICULUM VITAE

PERSONAL information

First Name: Na

Last Name: Liu

Sex: Female

Marital Status: Married

Place & Date of Birth: Shandong, China, June 22, 1977

Nationality: Chinese

Health: Excellent

Current Appointment: Associate professor of Medicine, Associate chief physician, PhD Supervisor, Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China

Overseas working and training experience in Sweden and U.S.A, focus on endoscopy procedure, treatments of gastrointestinal (GI) tract motility disorders and individual GI cancer therapy.

Clinical practice experience in the top digestive disease centre in China (ranked first from 2009 to 2019) for 17 years.

A well-trained GI doctor, good at diagnosis and treatment for common digestive diseases, including gastroesophageal reflux disease (GERD), peptic ulcer, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), liver disease and GI cancer. Speciality: GI cancer and GI motility disorders.

Also a skilled endocopist in esophagogastroduodenoscopy (EGD), colonscopy and ultrasound endoscopy (EUS) procedure.

Working in a teaching hospital and as a leading physician in GI cancer unit, gained extensive experience on training medical school students, residents and visiting physicians.

Sub-PI of more than 10 clinical trials.

CLINICAL WORK

2017.01-present: Associate chief physician, Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China

2004.07-2016.12: Attending physician, Xijing Hospital of Digestive Disease, Xijing Hospital, Fourth Military Medical University, Xi’an, China

2009.06-2009.12: Visiting physician, Division of gastroenterology and hepatology, Nebraska University medical center, Omaha, USA; Visiting physician, Division of gastroenterology, Barnes-Jewish Hospital, Washington University, St. Louis, USA

2001.08-2004.07: Resident, Xijing Hospital, Fourth Military Medical University, Xi’an, China

Education

2014.10-2016.08: Postdoctoral research fellow, Department of Oncology and Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden

Field: Identification of novel prognostic and predictive biomarkers and investigation of their underlying mechanisms in colorectal cancer

1999.08-2004.07: Ph.D., State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, China

Field: Role of Rho family proteins in gastric carcinogenesis and metastasis

1994.08-1999.07: M.D., Fourth Military Medical University, Xi’an, China

CLINICAL TRIAL EXPERIENCE (only cancer drug related showing here)

honorS

Frist prize of National Science and Technology Progress Awards (2008)

FUNDs

PI of four projects funded by National Natural Science Foundation of China

1. No. 81872397 Jan 2019-Dec 2022 Critical role of RhoB/Arl14 in regulating colorectal cancer EMT through Slit2/Robo1-Wnt/β-catenin pathway.

2. No. 81370484 Jan 2014-Dec 2017 Regulation of CDX2 by miR-92a in gastric intestinal metaplasia.

3. No. 30973423 Jan 2010-Dec 2012 Novel miRNA-mediated signalling pathway in gastric cancer.

4. No. 30400535 Jan 2005-Dec 2007 Role of RhoC in metastasis of gastric cancer.

Publications

1. Tantai XX, Yang LB, Wei ZC, Xiao CL, Chen LR, Wang JH, Liu N (corresponding author). Association of proton pump inhibitors with risk of hepatic encephalopathy in advanced liver disease: A meta-analysis. World J Gastroenterol. 2019 Jun 7;25(21):2683-2698. doi: 10.3748/wjg.v25.i21.2683. (IF=3.3)

2. Qiao L, Xie N, Bai Y, Li Y, Shi Y, Wang J, Liu N (corresponding author). Identification of upregulated HNRNPs associated with poor prognosis in pancreatic cancer. BioMed Res Int. 2019 Jul 4;2019:5134050. doi: 10.1155/2019/5134050. (IF=2.2)

3. Liu N, Cui W, Jiang X, Zhang Z, Gnosa S, Ali Z, Jensen L, Jönsson JI, Blockhuys S, Lam EW, Zhao Z, Ping J, Xie N, Kopsida M, Wang X, Sun XF.. The critical role of dysregulated RhoB signaling pathway in radio-resistance of rectal cancer. Int J Radiat Oncol Biol Phys. 2019 Apr 27. pii: S0360-3016(19)30653-4. doi: 10.1016/j.ijrobp.2019.04.021.(IF=6.2)

4. Wei Z, Liu N (corresponding author), Tantai X, Xing X, Xiao C, Chen L, Wang J. The effects of curcumin on the metabolic parameters of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Hepatol Int. 2018 Nov 16. doi: 10.1007/s12072-018-9910-x.(IF=4.1)

5. Tantai X, Yang L, Wei L, Xiao C, Chen L, Wang J, Liu N (corresponding author). Systematic Review with Meta-Analysis: Effects of Statins on the Hepatic Decompensation, Complications, Mortality and Drug Safety in Liver Cirrhosis. Gastroenterology, 154 (6) , S-1247. DOI: 10.1016/S0016-5085(18)34097-6 (IF=20.7 meeting abstract)

6. Kang X, Zhao L, Liu N (co-first author), Wang X, Zhang R, Liu Z, Liang S, Yao S, Tao Q, Jia H, Pan Y, Guo X.Activities in a social networking-based discussion group by endoscopic retrograde cholangiopancreatography doctors. Eur J Gastroenterol Hepatol. 2017 Oct;29(10):1131-1135. (IF=2.0)

7. Bai Y, Qiao L, Xie N, Shi Y, Liu N (corresponding author), Wang J. Expression and prognosis analyses of the Tob/BTG antiproliferative (APRO) protein family in human cancers. PLoS One. 2017 Sep 18;12(9):e0184902. doi: 10.1371/journal.pone.0184902. eCollection 2017(IF=2.9)

8. Liu N, Cox TR, Cui W, Homlund B, Ping J, Erler JT, Sun XF. Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients. Oncotarget. 2017;8(36):60015-60024. (IF=5.0)

9. Liu Q, Yao L, Xie H, Zhang DX, Zhang H, Guo C, Wu K, Liu N (corresponding author).High-resolution manometry and endoscopic ultrasonography are important for diagnosing congenital esophageal stenosis. J Dig Dis. 2015;16(8):479-82. (IF=1.9)

10. Zhang Z, Liu X, Feng B, Liu N (co-first author), Wu Q, Han Y, Nie Y, Wu K, Shi Y, Fan D.STIM1,a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer. Oncogene. 2015;34(37):4808-20. (IF=7.9)

11. Liu N, Pan Y, Li Z, Shi Y, Zhang X, Wu G, Wu K, Wang X. Neuromuscular and vascular hamartoma: a rare entity or special phase of Crohn's disease. J Dig Dis. 2015 Jan;16(1):52-4. (IF=1.9)

12. Liu N，Liu L, Zhang H, Gyawali CP, Zhang D, Yao L, Yang Y, Wu K, Ding J, Fan D. Effect of intravenous proton pump inhibitor regimens and timing of endoscopy on clinical outcomes of peptic ulcer bleeding. J of Gastroenterol Hepatol, 2012 Sep;27(9):1473-9. (IF=3.3)

13. Liu N, Zhang G, Bi F, Pan Y, Xue Y, Shi Y, Yao L, Zhao L, Zheng Y, Fan D.RhoC is essential for the metastasis of gastric cancer. J Mol Med. 2007 Oct;85(10):1149-56.(IF=5.1)

14. Liu N, Bi F, Pan Y, Sun L, Xue Y, Shi Y, Yao X, Zheng Y, Fan D.Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6239-47.(IF=8.9)

15. Liu N, Zhang H, Wu K, Fan D. What is the relationship between epidermal growth factor-like domain 7 and RhoC in metastasis of hepatocellular carcinoma?Hepatology. 2010 Jun;51(6):2235-6 (Correspondence)

16. Blockhuys S, Liu N, Agarwal NR, Enejder A, Loitto V, Sun XF. X-radiation enhances the collagen type I strap formation and migration potentials of colon cancer cells. Oncotarget. 2016 Nov 1;7(44):71390-71399.

17. Liu Z, Liu N, Zhang X, Pan Y, Guo X, Wu K. Effect of Endoscopic Submucosal Dissection on Esophagogastric Junction Physiology. Gastrointestinal Endoscopy, 2014, 79(5):AB221–AB222.

18. Gerjevic LN, Liu N,Lu S, Harrison-Findik DD. Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver.Int J Hepatol. 2012;2012:459278.

19. Bi F, Liu N, Fan D. Small interfering RNA: a new tool for gene therapy. Curr Gene Ther. 2003 Oct;3(5):411-7.

20. Zhang P, Liu N, Wang Y. Insulin may cause deterioration of proliferative diabetic retinopathy. Med Hypotheses. 2009 Mar;72(3):306-8.

21. Pan Y, Bi F, Liu N, Xue Y，Yao Y, Zheng Y, Fan D. Expression of seven main Rho family members in gastric carcinoma. Biochem Biophys Res Commun. 2004; 315(3)686-691.

22. Meng F, Ding J, Liu N, Zhang J, Shao X, Shen H, Xue Y, Xie H, Fan D. Inhibition of gastric cancer angiogenesis by vector-based RNA interference for Raf-1. Cancer Biol Ther. 2005 Jan;4(1):113-7. Epub 2005 Jan 8.

23. Hong L, Zhang Y, Liu N, Liu C, Zhi M, Pan Y, Lan M, Sun L, Fan D. Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene. BiochemBiophys Res Commun. 2004 Aug 27;321(3):611-6.

24. Wang MS, Pan Y, Liu N, Guo C, Hong L, Fan D.Overexpression of DARPP-32 in colorectal adenocarcinoma.Int J ClinPract. 2005 Jan;59(1):58-61

25. Zhou J, Zhu Y, Zhang G, Liu N, Sun L, Liu M, Qiu M, Luo D, Tang Q, Liao Z, Zheng Y, Bi F.A distinct role of RhoB in gastric cancer suppression.Int J Cancer. 2011 Mar 1;128(5):1057-68.

26. Xue Y, Bi F, Zhang X, Pan Y, Liu N, Zheng Y, Fan D. Inhibition of endothelial cell proliferation by targeting Rac1 GTPase with small interference RNA in tumor cells. BiochemBiophys Res Commun. 2004 Aug 6;320(4):1309-1315.

27. Liu C, Shi Y, Han Z, Pan Y, Liu N, Han S, Chen Y, Lan M, Qiao T, Fan D. Suppression of the dual-specificity phosphatase MKP-1 enhances HIF-1 trans-activation and increases expression of EPO. BiochemBiophys Res Commun. 2003 Dec 19;312(3):780-6.

28. Liu C, Shi Y, Du Y, Ning X, Liu N, Huang D, Liang J, Xue Y, Fan D. Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK.Exp Cell Res. 2005 Oct 1;309(2):410-8.

29. Shi Y, Zhang Y, Zhao Y, Hong L, Liu N, Jin X, Pan Y, Fan D. Overexpression of ZNRD1 Promotes Multidrug-Resistant Phenotype of Gastric Cancer Cells Through Upregulation of P-Glycoprotein. Cancer BiolTher. 2004 Apr;3(4):377-81.

30. Pan Y, Zhao L, Liang J, Liu J, Shi Y, Liu N, Zhang G, Jin H, Gao J, Xie H, Wang J, Liu Z, Fan D.Cellular prion protein promotes invasion and metastasis of gastric cancer. FASEB J. 2006 Sep;20((11):1886-8.

31. Xue Y, Bi F, Zhang X, Zhang S, Pan Y, Liu N, Shi Y, Yao X, Zheng Y, Fan D.Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation. Int J Cancer. 2006 Jun 15;118(12):2965-72.

32. Shen H, Pan YL, Han ZY, Hong L, Liu N, Han S, Yao L, Xie H, Fan D. Reversal of multidrug resistance of gastric cancer cells by downregulation of TSG101 with TSG101 siRNA. Cancer BiolTher. 2004, Jun;3(6):561-5.

33. Lan M, Shi Y, Han Z, Hao Z, Pan Y, Liu N, Guo C, Hong L, Wang J, Qiao T, Fan D. Expression of delayed rectifier potassium channels and their possible roles in proliferation of human gastric cancer cells. Cancer BiolTher. 2005 Dec;4(12):1342-7. Epub 2005 Dec 14.

34. Meng FP, Ding J, Yu ZC, Han QL, Guo CC, Liu N, Fan DM.Oral attenuated Salmonella typhimurium vaccine against MG7-Ag mimotope of gastric cancer. World J Gastroenterol. 2005 Mar 28;11(12):1833-6.

35. Du J, Pan Y, Shi Y, Guo C, Jin X, Sun L, Liu N, Qiao T, Fan D. Overexpression and significance of prion protein in gastric cancer and multidrug-resistant gastric carcinoma cell line SGC7901/ADR.Int J Cancer. 2005 Jan 10;113(2):213-20

36. Han Z, Wu K, Shen H, Li C, Han S, Hong L, Shi Y, Liu N, Guo C, Xue Y, Qiao T, Fan D.Akt1/protein kinase B alpha is involved in gastric cancer progression and cell proliferation.Dig Dis Sci. 2008 Jul;53(7):1801-10.

37. Liang J, Pan YL, Ning XX, Sun LJ, Lan M, Hong L, Du JP, Liu N, Liu CJ, Qiao TD, Fan DM.Overexpression of PrPC and its antiapoptosis function in gastric cancer.Tumour Biol. 2006;27(2):84-91.

38. Hong L, Zhang Y, Han S, Wang J, Shi Y, Pan Y, Liu N, Zhang X, Fan D.Preparation and characterization of a novel monoclonal antibody specific to human ZNRD1 protein. Hybrid Hybridomics. 2004 Feb;23(1):65-8.

39. Jin H, Wang Z, Liu L, Gao L, Sun L, Li X, Zhao H, Pan Y, Shi H, Liu N, Hong L, Liang J, Wu Q, Yang Z, Wu K, Fan D.R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction. Mol Pharm. 2010 Feb 1;7(1):156-68.

40. Xiaong XL, Wang A, Tu L, Ke MY,Yang YS, Jiang B, Lin L, Dai N, Zhang SS, Tao L, Xu H, Liang XM, Fang XC,Xia ZW, Wang X, Wu JN, Wang MF, Zhang HJ, Fang YF, Shen C, Wang J, Peng LH, Li WY, Wang ZF, Wang K, Liu N, Hou XH. The motility of esophageal sphincters during liquid and solid bolus swallows: a multicenter normative value study of high-resolution manometry in China. Neurogastroenterol Motil. 2016 Sep 25. doi: 10.1111/nmo.12914. [Epub ahead of print]

41. Jia H, Pan Y, Guo X, Zhao L, Wang X, Zhang L, Dong T, Luo H, Ge Z, Liu J, Hao J, Yao P, Zhang Y, Ren H, Zhou W, Guo Y, Zhang W, Chen X, Sun D, Yang X, Kang X, Liu N, Liu Z, Leung F, Wu K, Fan D. Water Exchange Method Significantly Improves Adenoma Detection Rate: A Multicenter, Randomized Controlled Trial. Am J Gastroenterol. 2017 Apr;112(4):568-576.