Ming Zhang

CURRICULUM VITAE

PERSONAL INFORMATION

Name: Ming Zhang, Ph.D.

Gender: Male 　　Birth date: 30/03/1985

Deputy chief physician/Associate research fellow

Department of Respiratory and Critical Care Medicine,

The Second Affiliated Hospital of Xi’an Jiaotong University,

Xi’an, Shaanxi, China

Tel. 86 29 87679971

Mobile No. 86 13259919643

Email: zhangmingdr@163.com

EDUCATION

9/2019-9/2020Visiting researcher, Department of Biomedicine, University of Basel, Switzerland (Mentor: Prof. Michael Roth)

9/2010-12/2013Doctorate in Internal Medicine, Xi’an Jiaotong University Health Science Center, Xi’an, China (Mentor: Prof. Jin Wei)

9/2007-7/2010Master Degree in Internal Medicine, Xi’an Jiaotong University Health Science Center, Xi’an, China (Mentor: Prof. Yali Li)

9/2002-7/2007Bachelor Degree in Clinical Medicine, Xi’an Jiaotong University Health Science Center, Xi’an, China

PROFESSIONAL EXPERIENCES

1/2021-presentDeputy chief physician/Associate research fellow, Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

1/2017-12/2020Attending physician/Associate research fellow, Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

7/2015-12/2016Attending physician/Assistant research fellow, Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

12/2013-6/2015Resident physician/Assistant research fellow, Internal Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

MEMBERSHIP

Youth Committee of Respiratory Rehabilitation of China Rehabilitation Medicine Association

Cardiopulmonary Rehabilitation Committee of Shaanxi Province

PUBLICATION (first or corresponding author)

1. Ming Zhang, Lei Fang, Liang Zhou, Antonio Molino, Maria Rosaria Valentino, Shuanying Yang, Jie Zhang, Yali Li, Michael Roth*. MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell in chronic obstructive pulmonary disease. Free Radical Bio Med, 2021, 172: 541-549. (IF=7.376)

2. Ming Zhang*, Yeli Zhang, Michael Roth, Li Zhang, Rong Shi, Xia Yang, Yali Li, Jie Zhang. Sirtuin 3 inhibits airway epithelial mitochondrial oxidative stress in cigarette smoke-induced COPD. Oxid Med Cell Longev, 2020, 2020: 7582980. (IF=6.543)

3. Ming Zhang, Rong Shi, Yeli Zhang, Hu Shan, Qiuhong Zhang, Xia Yang, Yali Li*, Jie Zhang*. Nix/BNIP3L-dependent mitophagy accounts for airway epithelial cell injury induced by cigarette smoke. J Cell Physiol, 2019, 234(8): 14210-14220. (IF=5.546)

4. Ming Zhang, Jingjing Tang, Hu Shan, Qiuhong Zhang, Xia Yang, Jie Zhang, Yali Li*. p66Shc mediates mitochondrial dysfunction dependent on PKC activation in airway epithelial cells induced by cigarette smoke. Oxid Med Cell Longev, 2018, 2018: 5837123. (IF=4.936)

5. Ming Zhang, Jingjing Tang, Jiafeng Yin, Xiaoying Wang, XiangliFeng, Xia Yang, Hu Shan, Qiuhong Zhang, Jie Zhang, Yali Li*. The clinical implication of serum cyclophilin A in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 2018, 13: 357-363. (IF=2.917)

6. Ming Zhang*, Jingjing Tang, Yali Li, YingyingXie, Hu Shan, Mingxia Chen, Jie Zhang, Xia Yang, Qiuhong Zhang, Xudong Yang. Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats: PGC-1α/SIRT3 pathway involved. ChemBiol Interact, 2017, 277: 168-175. (IF=3.296)

7. Ming Zhang, YingyingXie, Rui Yan, Hu Shan, Jingjing Tang, Yan Cai, Jiafeng Yin, Mingxia Chen, Jie Zhang, Xia Yang, Qiuhong Zhang, Yali Li*. Curcumin ameliorates alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease. Life Sci, 2016, 164: 1-8. (IF=2.936)

8. Ming Zhang, Yali Li, Xia Yang, Hu Shan, Qiuhong Zhang, Zongjuan Ming, YingyingXie, Haijuan Chen, Yanqin Liu, Jie Zhang*. Serum cystatin C as an inflammatory marker in exacerbated and convalescent COPD patients. Inflammation, 2016, 39(2): 625-631. (IF=2.955)

9. Ming Zhang, Jie Zhang, Qiuhong Zhang, Xia Yang, Hu Shan, Zongjuan Ming, Haijuan Chen, Yanqin Liu, Jiafeng Yin, Yali Li*. D-dimer as a potential biomarker for the progression of COPD. ClinChimActa, 2016, 455: 55-59. (IF=2.873)

10. Ming Zhang*, Yali Li, Jie Zhang, Qiuhong Zhang, Xia Yang, Hu Shan, YingyingXie, Qingjin Jin, XiangliFeng. Mean platelet volume is elevated in exacerbated and convalescent COPD patients. ClinChimActa, 2015, 451: 227-231. (IF=2.799)

11. Ming Zhang, Jin Wei*, Yali Li, Hu Shan, Rui Yan, Lin Lin, Qiuhong Zhang, JiahongXue. Novel distribution of calreticulin to cardiomyocyte mitochondria and its increase in a rat model of dilated cardiomyopathy. BiochemBioph Res Co, 2014, 449(1): 62-68. (IF=2.297)

12. Ming Zhang, Jin Wei*, Hu Shan, Hao Wang, Yanhe Zhu, JiahongXue, Lin Lin, Rui Yan. Calreticulin-STAT3 signaling pathway modulates mitochondrial function in a rat model of furazolidone-induced dilated cardiomyopathy. Plos One, 2013, 8(6): e66779. (IF=3.534)

13. Ming Zhang, Jingjing Tang, YingyingXie, Jie Zhang, Qiuhong Zhang, Xia Yang, Hu Shan, Yali Li*. Effect of curcumin on endoplasmic reticulum stress of alveolar epithelial cells in a rat model of chronic obstructive pulmonary disease. J Xi’an JiaotongUniv (Med Sci), 2018,39 (3): 361-365.

14. Ming Zhang*, YingyingXie, Yali Li, Shuanying Yang, Jie Zhang, Jingjing Tang, Xia Yang, Hu Shan, XiangliFeng. Effect of curcumin on the expression of IL-1β and IL-17 in a rat model of chronic obstructive pulmonary disease. Int J Respir, 2017, 37(7): 488-493.

15. Ming Zhang, Yali Li, Xia Yang, Hu Shan, Qiuhong Zhang, XiangliFeng, YingyingXie, Jingjing Tang, Jie Zhang*. Clinical significance of serum carbohydrate antigen 125 in acute exacerbation of chronic obstructive pulmonary disease. J South Med Univ, 2016,36 (10): 1386-1389.

16. Ming Zhang, Jin Wei*, Hu Shan, Rui Yan, Lin Lin, Yanhe Zhu. Effects of p66shc Adapter Protein and Estrogen on Cardiomyocyte Apoptosis Induced by Angiotensin II. J Sichuan Univ (Med Sci Edi), 2014, 45(2): 202-206.

17. Ming Zhang, Jin Wei*, Xiaoqing Pan, Hu Shan, Rui Yan, JiahongXue, Yanhe Zhu, Lin Lin. Change of cardiac mitochondrial STAT3 activity in rats with selenium deficiency and its relation with myocardial injury. J South Med Univ, 2013,33 (7): 967-971.

18. Ming Zhang, Jin Wei*, Xiaoqing Pan, Rui Yan, Yanhe Zhu, Hu Shan. Effects of thioredoxin 2 on the mitochondrial structure and function in selenium deficiency rat hearts. J Xi’an JiaotongUniv (Med Sci), 2013,34(5): 599-603.

RESEARCH INTERESTS

Dr. Zhang’s research interests are focused in the fields of chronic obstructive pulmonary disease (COPD). He found several serum inflammatory markers for the progression of COPD. He also explored the roles of airway epithelial mitochondrial injury in the pathogenesis of COPD.

GRANTS (PI: Ming Zhang)

1. Innovation Capability Support Program of Shaanxi, 2019KJXX-045, The role of Sirt3-mitoROS signaling pathway in airway epithelial mitochondrial damage in the pathogenesis of COPD, 2019/01-2021/12, CNY100,000

2. National Nature Science Foundation of China, 81600030, PKCs-p66Shc signaling pathway modulates mitochondrial function of airway epithelial cell in the pathogenesis of COPD, 2017/01-2019/12, CNY180,000

3. Special Scientific Research Funds for Personnel Training of the Second Affiliated Hospital of Xi'an Jiaotong University, RC(XM)201604, Protective effect of curcumin on COPD and the underlying mechanism, 2017/01-2019/12, CNY40,000

4. Natural Science Basic Research Project of Shaanxi Province, 2016JQ8048, Curcumin ameliorates airway epithelial mitochondrial damage in COPD through the regulation of p66Shc, 2016/01-2017/12, CNY30,000

5. Fundamental Research Funds for the Central Universities of China, xjj2015030, The molecular mechanism of mitochondria in the pathogenesis of COPD based on adaptor protein p66Shc, 2015/01-2017/12, CNY80,000

6. Youth Funds of the Second Affiliated Hospital of Xi'an Jiaotong University, YJ(QN)201410, The role of p66Shc in the mitochondrial injury of airway epithelial cell in the patients with COPD, 2015/01-2017/12, CNY10,000

TEACHING ACTIVITIES

2015-present: Internal Medicine and Diagnostics for medical students, Xi’an, China

HONORS AND AWARDS

Science and Technology Youth Star of Shaanxi Province (2018)