Ji WenCheng

Jiwen Cheng

Ph.D., Associate Professor

Department of Pediatric Surgery

The Second Affiliated Hospital of Xi’an Jiaotong University

No. 157 West 5 Road, Xi’an, Shaanxi 710004, P.R.China

Email: jiwencheng68999@xjtu.edu.cn

Phone: +86 133-8926-7326

Curriculum Vita

Academic career:

Education:

Research Interests

■ Molecular markers for diagnosis, prognosis, and targeted therapy of cancer.

■ Association between gene polymorphism and risk of solid tumors in children.

■ The roles of Vitamin D receptor play in the development of congenital biliary atresia.

■ Pathogenesis of congenital biliary atresia

Grants:

■ 2019.1-2021.12 National Natural Science Foundation of China (PI, Grant No. 81800450), focused on the role and mechanism of vitamin D receptor in bile duct epithelial injury during the pathogenesis of biliary atresia.

■ 2019.1-2021.12 The Fundamental Scientific Research Business Expenses of Central Universities (PI, Grant No. XJJ2018126), focused on the molecular mechanism of Lin28B/let-7b targeting SALL4 in regulating malignant behavior of hepatoblastoma

■ 2020.1-2021.12 The Key R& D Program of Shaanxi Province (PI, Grant No. S2020-YF-YBSF-0245), focused on the role and mechanism of VDR in cholangitis after Kasai portoenterostomy in patients with biliary atresia.

Publications

■ Cheng J, Zhuo Z, Yang L, et al. HMGA2 gene polymorphisms and Wilms tumor susceptibility in Chinese children: a four-center case-control study. Biotechnol Appl Biochem. 2020;67(6):939-45.

■ Cheng J, Wei K, Xin Y, et al. Lack of associations between LIG3 gene polymorphisms and neuroblastoma susceptibility in Chinese children. J Cancer. 2019;10(23):5722-6.

■ Cheng J, Zhuo Z, Zhao P, et al. PARP1 gene polymorphisms and neuroblastoma susceptibility in Chinese children. J Cancer. 2019;10(18):4159-64.

■ Cheng J, Zhuo Z, Xin Y, et al. Relevance of XPD polymorphisms to neuroblastoma risk in Chinese children: a four-center case-control study. Aging (Albany NY). 2018;10(8):1989-2000.

■ Cheng J, Chen Y, Zhao P, et al. Dysregulation of miR-638 in hepatocellular carcinoma and its clinical significance. Oncol Lett. 2017;13(5):3859-65.

■ Cheng J, Chen Y, Zhao P, et al. Downregulation of miRNA-638 promotes angiogenesis and growth of hepatocellular carcinoma by targeting VEGF. Oncotarget. 2016 24;7(21):30702-11.

■ Cheng J, Zhao P, Liu J, et al. Preoperative aspartate aminotransferase-to-platelet ratio index (APRI) is a predictor on postoperative outcomes of hepatocellular carcinoma. Medicine (Baltimore). 2016;95(48):e5486.

■ Cheng J, Li M, Lv Y. Sub-lethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma. Hepatology, 2014; 59(4):1650.

■ Cheng J, Lv Y. Pre-retrieval reperfusion decreases cancer recurrence after rat ischemic liver graft transplantation. J Hepatol, 2014, 61(4):962.

■ Cheng J, Wang W, Sun C, et al. Meta-Analysis of the Prognostic and Diagnostic Significance of Serum/Plasma Osteopontin in Hepatocellular Carcinoma. J Clin Gastroenterol. 2014, 48(9):806-14.

■ Cheng J, Wang W, Zhang Y, et al. Prognostic Role of Pre-Treatment Serum AFP-L3% in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis. PLoS One, 2014, 9(1):e87011.

■ Cheng J, Lv Y. New progress of non-surgical treatments for hepatocellular carcinoma. Med Oncol, 2013, 30(1):381.

■ Yang W, Zhao P, Cao P,…, Cheng J. Global interpretation of novel alternative splicing events in human congenital pulmonary airway malformations: A pilot study. J Cell Biochem. 2022;123(4):736-45.

■ Yang W, Zhao P, Liu Y,…, Cheng J. Transcriptome analysis of lncRNA expression patterns in human congenital lung malformations. BMC Genomics. 2021;22(1):861.

■ Yang W, Shen C, Yu N,…, Cheng J*. Computer-aided quantitative MSCT measurements may be useful for congenital lung malformations surgical approach selection. Pediatr Surg Int. 2021;37(9):1273-80.

■ Liu J, Jia W, Hua RX,…, Cheng J*. APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study. Oxid Med Cell Longev. 2019;2019:5736175.

■ Li L, Zhu J, Lu T,…, Cheng J*. Association of miR-34b/c rs4938723 and TP53 Arg72Pro Polymorphisms with Neuroblastoma Susceptibility: Evidence from Seven Centers. Transl Oncol. 2019;12(10):1282-8.

Honours and Awards

■ 2018: Excellent Paper Award in 13th Annual Congress of the Chinese Society of Pediatric Surgery

■ 2017: Young Stars in Science and Technology of Shaanxi Province