Yumin Xia

Name: Yumin Xia, MD, PhD

Position: Professor in Dermatology, Director of Scientific Research Department

Affiliation: The Second Affiliated Hospital of Xi’an Jiaotong University (XJTU)

Address: 157 Xiwu Road, Xi'an 710004, China

Phone: +86-29-87678324

Email: xiayumin1202@163.com; yuminxia@mail.xjtu.edu.cn

Areas of research

We study the molecular mechanisms underlying the organ injuries in patients with systemic lupus erythematosus, with a particular interest in the pathogenicity of autoantibodies. We also study the roles of TWEAK/Fn14 signalling axis in inflammatory responses in various skin diseases.

Education

Sept 2003-Nov 2006 Doctor in Internal Medicine, Wuhan University

Sept 1998-Jul 2001 Master in Dermatology, Wuhan University

Sept 1993-Jul 1998 Bachelor in Clinical Medicine, Tongji Medical University (continued by Huazhong University of Science & Technology)

Postdoctoral training

Jan 2010-Dec 2013 Department of Microbiology & Immunology, Albert Einstein College of Medicine, USA

May 2009-Dec 2009 Department of Dermatology/Wellman Center for Photomedicine, Massachusetts General Hospital of Harvard University, USA

Faculty appointments

Jan 2020-present Professor in Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, China

Aug 2014-Dec 2019 Associate Professor in Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, China

Jan 2014-Aug 2014 Associate, Department of Microbiology & Immunology, Albert Einstein College of Medicine, USA

Dec 2007- May 2009 Associate Chief Physician, Department of Dermatology, Renmin Hospital of Wuhan University, China

Jun 2005-Nov 2007 Attending Physician, Department of Dermatology, Renmin Hospital of Wuhan University, China

Jul 2001-May 2005 Resident, Department of Dermatology, Renmin Hospital of Wuhan University, China

Grants (as principal investigator)

2022-2025 The TWEAK/Fn14 signals regulate hair follicle stem cells and enhance wound epithelialization. No.82173445, The National Natural Science Foundation of China (NSFC).

2022-2025 The roles of TWEAK/Fn14 signalling axis in the diagnosis and therapies of skin diseases. Special Support Plan for High-Level Talents of Shaanxi Province

2020-2022 The TWEAK-based psoriasis severity evaluation and target therapy. No.2020ZDLSF02-08, The Key Research and Development Plan of Shaanxi Province.

2019-2022 An innovative research team for immunological skin diseases. No.2019TD-034, The Innovation Capability Support Plan of Shaanxi Province.

2019-2022 Anti-dsDNA IgG induces renal fibrosis through repressing SOCS1 signals. No.81874241, The National Natural Science Foundation of China (NSFC).

2018-2018 Therapeutic effect of cold atmospheric plasma on cutaneous malignancies and precancerous lesions. No.PY3A038, The World-Class Universities (Disciplines) and the Characteristic Development Guidance Funds for the Central Universities.

2017-2021 TWEAK/Fn14 signaling modulates keratinocytes bidirectionally and emerges as therapeutic target under inflammatory microenvironments. No.81630081, The National Natural Science Foundation of China (NSFC).

2017-2019 An Fn14-TRAF2-TNFR axis: novel target for the treatment of psoriasis? No.2017ZDJC-06, The Natural Science Foundation of Shaanxi Province.

2015-2021 Young Talent Support Plan of XJTU. No.2015qngz01.

2015-2018 TWEAK/Fn14 activation is pivotal in the renal pathogenicity of anti-dsDNA antibodies. No.81472876, The National Natural Science Foundation of China (NSFC).

2014-2019 The roles of TWEAK/Fn14 pathway in the pathogenesis of skin diseases (photosensitization and psoriasis). The Start-up Fund from the Second Affiliated Hospital of XJTU.

2010-2012 Anti-dsDNA antibodies induce the phenotypic changes of mesangial cells by interacting with α-actinin. No.30972640, The National Natural Science Foundation of China (NSFC).

2008-2010 Plasmacytoid dendritic cell vaccine blocks the production of anti-dsDNA antibodies. No.30700725, The National Natural Science Foundation of China (NSFC).

Top10 original publications

1. Zhai S, Xu M, Li Q, Guo K, Chen H, Kong MG, Xia Y. Successful treatment of vitiligo with cold atmospheric plasma-activated hydrogel. J Invest Dermatol, 2021;141(11):2710-2719.e6.

2. Guo M, Wang H, Xu S, Zhuang Y, An J, Su C, Xia Y, Chen J, Xu ZZ, Liu Q, Wang J, Dan Z, Chen K, Luan X, Liu Z, Liu K, Zhang F, Xia Y, Liu X. Alteration in gut microbiota is associated with dysregulation of cytokines and glucocorticoid therapy in systemic lupus erythematosus. Gut Microbes. 2020;11(6):1758-1773.

3. Hu G, Liang L, Liu Y, Liu J, Tan X, Xu M, Peng L, Zhai S, Li Q, Chu Z, Zeng W, Xia Y. TWEAK/Fn14 interaction confers aggressive properties to cutaneous squamous cell carcinoma. J Invest Dermatol, 2019, 139: 796-806.

4. Liu J, Liu Y, Peng L, Li J, Wu K, Xia L, Wu J, Wang S, Wang X, Liu Q, Zeng W, Xia Y. TWEAK/Fn14 signals mediate burn wound repair. J Invest Dermatol, 2019;139(1):224-234.

5. Liu Y, Peng L, Li L, Liu C, Hu X, Xiao S, Xia Y. TWEAK/Fn14 activation contributes to the pathogenesis of bullous pemphigoid. J Invest Dermatol. 2017;137(7):1512-1522.

6. Liu X, Liu Y, Xu M, Li J, Teng X, Cheng H, Xia Y. Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol. Br J Dermatol. 2016; 175(2): 314-24.

7. Cheng H, Zhan N, Ding D, Liu X, Zou X, Li K, Xia Y. HPV type 16 infection switches keratinocytes from apoptotic to proliferative fate under TWEAK/Fn14 interaction. J Invest Dermatol. 2015;135(10):2427-36.

8. Zou XY, Ding D, Zhan N, Liu XM, Pan C, Xia YM. Glyoxalase I is differentially expressed in cutaneous neoplasms and contributes to the progression of squamous cell carcinoma. J Invest Dermatol. 2015;135(2):589-98.

9. Xia Y, Herlitz LC, Gindea S, Wen J, Pawar RD, Misharin A, Perlman H, Wu L, Wu P, Michaelson JS, Burkly LC, Putterman C. Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis. J Am Soc Nephrol. 2015;26(5):1053-70.

10. Xia Y, Pawar RD, Nakouzi AS, Herlitz L, Broder A, Liu K, Goilav B, Fan M, Wang L, Li QZ, Casadevall A, Putterman C. The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies. J Autoimmun. 2012;39(4):398-411.

Oral presentation in international conferences

Nov 26-29, 2020. Risk aversion for the application of retinoids beyond package inserts. The 26th Annual Meeting of Chinese Society for Dermatology. Hangzhou, China

Jun 20-23, 2018. TWEAK/Fn14 signals mediate burn wound repair. The 5th Eastern Asia Dermatology Congress EADC2018. Kunming, China

Nov 16-18, 2016. 1) TWEAK/Fn14 activation exacerbates Ro52-mediated photosensitization in cutaneous lupus erythematosus. 2) Transcription factor 7-like 1 (Tcf7l1) dysregulates keratinocyte differentiation through upregulating lipocalin 2. The 4th Eastern Asia Dermatology Congress EADC2016. Tokyo, Japan

May 2-6, 2014. Fn14 deficiency preserves the filtration barrier and ameliorates lupus nephritis. Centenial Annual Meeting of American Association of Immunologist (AAI). Pittsburgh, USA