Yongping Shao

Education

2001-2007 Ph.D. in Molecular Biology　　State University of New York at Albany

1997-2000 M.S. in Botany　　　　　　　　Fudan University, Shanghai, China

1993-1997 B.S. in Biology　　　　　　　　Fudan University, Shanghai, China

Award

2011　　Jefferson Postdoctoral Research Symposium Poster Presentation Award

2011　　Jefferson Collage of Graduate Study Postdoctoral Travel Fellowship

2010　　“Outrun the Sun” National Melanoma Research Scholar Award

2007　　Distinguished Doctoral Dissertation Award, SUNY Albany 2004 “Dr. Peter Marfey” Book Scholarship, SUNY Albany

Experience

2016-now 　Professor

　　　　　　Frontier Institute of Science and Technology, Xi’an Jiaotong University

2013-2016　Associate Professor

　　　　　　Frontier Institute of Science and Technology, Xi’an Jiaotong University

2008-2013　Postdoctoral Fellow

　　　　　　Kimmel Cancer Center, Thomas Jefferson University

2007-2008　Postdoctoral Associate

　　　　　　Department of Biological Science, University at Albany

Grants

1. The functional mechanism of β-Catenin Y142 phosphorylation in hepatocellular carcinoma. Grant #: 31970724, National Nature Science Foundation of China. 2020/01-2023/12, ¥580,000.

2. The regulation of ERBB3-mediated adaptive resistance to RAF inhibitors in mutant BRAF melanoma. Grant #: 31771557，National Nature Science Foundation of China. 2018/01-2021/12，¥600,000.

Publications

Corresponding author (#)

1. Wang M, Wang Y, Zhang M, Duan Q, Chen C, Sun Q, Liu M, Zheng Y#, Shao Y#. Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect. 2021. J Cell Physiol. 237(1):1044-1056.

2. Zhi Z, Ouyang Z, Ren Y, Cheng Y, Liu P, Wen Y, Shao Y#. Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis. 2021. Cell Death Differ. 29(2):323-336.

3. Han S, Yan Y, Ren Y, Hu Y, Wang Y, Chen L, Zhi Z, Zheng Y, Shao Y#, Liu J#. LncRNA SAMMSON Mediates Adaptive Resistance to RAF Inhibition in BRAF-Mutant Melanoma Cells. 2021. Cancer Res. 81(11):2918-2929.

4. Ren Y, Ouyang Z, Hou Z, Yan Y, Zhi Z, Shi M, Du M, Liu H, Wen Y#, Shao Y#. CIC Is a Mediator of the ERK1/2-DUSP6 Negative Feedback Loop. 2020. iScience. 2020 23(11):101635. doi: 10.1016/j.isci.2020.101635.

5. Jing R, Ma B, Qi T, Hu C, Liao C, Wen C, Shao Y#, Pei C#. Long Noncoding RNA OIP5-AS1 Inhibits Cell Apoptosis and Cataract Formation by Blocking POLG Expression Under Oxidative Stress. 2020. Invest Ophthalmol Vis Sci. 61(12):3. doi: 10.1167/iovs.61.12.3.

6. He W*, Yan J*, Sui F, Wang S, Su X, Qu Y, Yang Q, Guo H, Ji M, Lu W, Shao Y#, Hou P#. Turning a Luffa Protein into a Self-Assembled Biodegradable Nanoplatform for Multitargeted Cancer Therapy. 2018. ACS Nano. 12(11):11664-11677. doi: 10.1021/acsnano.8b07079.

7. Chen C, Wu N, Duan Q, Yang H, Wang X, Yang P, Zhang M, Liu J, Liu Z, Shao Y#, Zheng Y#. C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes. 2018. Sci Rep. 8(1):8590. doi: 10.1038/s41598-018-26996-z.

8. Xu D*, Liao C*, Zhang B, Tolbert D, He W, Dai Z, Zhang W, Yuan W, Pazgier M, Liu J, Yu J, Sansonetti P, Bevins C, Shao Y#, Lu W#. Human enteric α-Defensin 5 promotes Shigella infection by enhancing bacterial adhesion and invasion. 2018. Immunity. 48(6):1233-1244. (FEATURED ARTICLE)

9. Han S, Ren Y, He W, Liu H, Zhi Z, Zhu X, Yang T, Rong Y, Ma B, Ren Y, Purwin T, Ouyang Z, Li C, Wang X, Wang X, Yang H, Zheng Y, Aplin AE, Liu J#, Shao Y#. ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma. 2018. Nat Commun. 9(1):28. doi: 10.1038/s41467-017-02354-x.

10. Xu D*, Zhang B*, Liao C, Zhang W, Wang W, Chang Y, Lu W, Shao Y#. Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling. 2016. Oncotarget. 7(46):75902-75913.

11. Xu D*#, Zhang W*, Zhang B, Liao C, Shao Y#. Characterization of a biofilm-forming Shigella flexneri phenotype due to deficiency in Hep biosynthesis. 2016. Peer J. 4:e2178. doi: 10.7717.

12. Jia J, Liu F, Luo S, Li C, Yang J, Wang X, Wang N, Lai B, Lei T, Wang Q, Xiao S, Shao Y#, Zheng Y#. Yes-associated protein contributes to the development of human cutaneous squamous cell carcinoma via activation of Ras. 2016. J Invest Dermatol. 136(6):1267-77.

First author

13. Shao Y, Le K, Cheng H, Aplin AE#. NFκB-Regulation of c-FLIP Promotes TNFα-Mediated RAF Inhibitor Resistance in Melanoma. 2015. J Invest Dermatol. 135(7):1839-48.

14. Shao Y and Aplin AE#. BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma. 2012. Cell Death Differ. 19:2029-39.

15. Shao Y and Aplin AE#. ERK-regulated phosphorylation of serine 77 regulates Bmf pro-apoptotic activity. 2012. Cell Death Dis. 3(1):e253.

16. Shao Y and Aplin AE#. Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells. 2010. Cancer Res. 15; 70(16):6670-81.

17. Shao Y and Wang IN#. Effect of late promoter activity on bacteriophage lambda fitness. 2009. Genetics. 181(4):1467-75.

18. Shao Y and Wang IN#. Bacteriophage adsorption rate and optimum lysis time. 2008. Genetics. 180(1):471-82.

19. Shao Y, Feldman-Cohen LS, Osuna R#. Biochemical identification of base and phosphate contacts between Fis and a high affinity DNA binding site. 2008. J Mol Biol. 380(2):327-39.

20. Shao Y, Feldman-Cohen LS, Osuna R#. Functional characterization of the Escherichia coli Fis-DNA binding sequence. 2008. J Mol Biol. 376(3):771-85.

Others

21. Feng C, Huang Y#, He W, Cheng X, Liu H, Huang Y, Ma B, Zhang W, Liao C, Wu W, Shao Y, Xu D, Su Z#, Lu W#. Tanshinones: First-in-Class Inhibitors of the Biogenesis of the Type 3 Secretion System Needle of Pseudomonas aeruginosa for Antibiotic Therapy. 2019. ACS Cent Sci. 5(7):1278-1288.

22. Ma B, Niu F, Qu X, He W, Feng C, Wang S, Ouyang Z, Yan J, Wen Y, Xu D, Shao Y, Ma PX, Lu W#. A tetrameric protein scaffold as a nano-carrier of antitumor peptides for cancer therapy. 2019. Biomaterials. 204:1-12.

23. He W, Wang S, Yan J, Qu Y, Jin L, Sui F, Li Y, You W, Yang G, Yang Q, Ji M, Shao Y, Ma PX#, Lu W#, Hou P#. Self-Assembly of therapeutic peptide into stimuli-responsive clustered nanohybrids for cancer-targeted therapy. 2019. Adv Funct Mater. 29(10).

24. Qu X, Liu Z, Ma B, Li N, Zhao H, Yang T, Xue Y, Zhang X, Shao Y, Chang Y, Xu, J, Lei B#, Du Y#. All in one theranostic nanoplatform enables efficient anti-tumor peptide delivery for triple-modal imaging guided cancer therapy. 2019. Nano Res. 12 (3), 593-599.

25. Jing X, Zhi Z, Jin L, Wu Y, Wang D, Yan K, Shao Y, Meng L#. pH/redox dual-stimuli responsive cross-linked polyphosphazene nanoparticles for multimodal imaging guided chemo-photodynamic therapy. 2019. Nanoscale. doi: 10.1039/c9nr01194c

26. Liu J, Xu D, Li J, Gao N, Liao C, Jing R, Wu B, Ma B, Shao Y, Pei C#. The role of focal adhesion kinase in transforming growth factor-β2 induced migration of human lens epithelial cells. 2018. Int J Mol Med. 42(6):3591-3601.

27. Li C, Xiao L, Jia J, Li F, Wang X, Duan Q, Jing H, Yang P, Chen C, Wang Q, Liu J, Shao Y, Wang N, Zheng Y#. Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via PI3K-Akt Pathways. 2019. J Invest Dermatol. 139(1):71-80.

28. Niu F, Yan J, Ma B, Li S, Shao Y, He P, Zhang W, He W, Ma PX, Lu W#. Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy. 2018. Biomaterials. 167:132-142.

29. Yan J, He W#, Yan S, Niu F, Liu T, Ma B, Shao Y, Yan Y, Yang G, Lu W, Du Y, Lei B#, Ma PX. Self-Assembled Peptide-Lanthanide Nanoclusters for Safe Tumor Therapy: Overcoming and Utilizing Biological Barriers to Peptide Drug Delivery. 2018. ACS Nano. 12(2):2017-2026.

30. Jing X, Zhi Z, Wang D, Liu J, Shao Y, Meng L#. Multifunctional Nanoflowers for Simultaneous Multimodal Imaging and High-Sensitivity Chemo-Photothermal Treatment. 2018. Bioconjug Chem. 29(2):559-570.

31. Wang D*, Ren Y*, Shao Y, Yu D, Meng L#. Facile preparation of doxorubicin-loaded and folic acid-conjugated carbon nanotubes@poly(N-vinyl pyrrole) for targeted synergistic chemo-photothermal cancer treatment. 2017. Bioconjug Chem. 28(11):2815-2822.

32. Bu B, Tong X, Li D, Hu Y, He W, Zhao C, Hu R, Li X, Shao Y, Liu C, Zhao Q, Ji B, Diao J#. N-Terminal Acetylation Preserves α-Synuclein from Oligomerization by Blocking Intermolecular Hydrogen Bonds. 2017. ACS Chem Neurosci. 8(10):2145-2151.

33. Wen Y, Ouyang Z, Devreese B, He W, Shao Y, Lu W, Zheng F. Crystal structure of master biofilm regulator CsgD regulatory domain reveals an atypical receiver domain. 2017. Protein Sci. 26(10):2073-2082.

34. Zhang P, Wang Y, Lian J, Shen Q, Wang C, Ma B, Zhang Y, Xu T, Li J, Shao Y, Xu F#, Zhu JJ#. Engineering the surface of smart nanocarriers using a pH-/thermal-/GSH-responsive polymer zipper for precise tumor targeting therapy in vivo. 2017. Adv Mater. doi: 10.1002/adma.201702311.

35. Jia J, Zheng Y#, Wang W, Shao Y, Li Z, Wang Q, Wang Y, Yan H. Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells. 2017. Mol Med Rep. 15(1):240-248.

36. Wang W, Zheng Y#, Jia J, Li C, Duan Q, Li R, Wang X, Shao Y, Chen C, Yan H. Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1. 2017. Exp Ther Med. 14(1):499-506.

37. Wang D*, Ren Y*, Shao Y, Meng L#.Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy. 2017. Polym. Chem. 8: 6938-6942.

38. Wu Y, Wang L, Guo B#, Shao Y, Ma PX#. Electroactive Biodegradable Polyurethane Significantly Enhanced Schwann Cells Myelin Gene Expression and Neurotrophin Secretion for Peripheral Nerve Tissue Engineering. 2016. Biomaterials. 87:18-31.

39. Yan Z, Qu K, Zhang J, Huang Q, Qu P, Xu X, Yuan P, Huang X, Shao Y, Liu C, Zhang H, Xing J#. CD147 promotes liver fibrosis progression via VEGF-A/VEGFR2 signalling-mediated cross-talk between hepatocytes and sinusoidal endothelial cells. 2015. Clin Sci (Lond). 129(8):699-710.

40. Dai Z#, Shao Y, Kang H, Tang W, Xu D, Zhao Y, Liu D, Wang M, Yang P, Wang X. Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis. 2015. World J Gastroenterol. 21(16):5081-9. doi: 10.3748/wjg.v21.i16.5081.

41. Du Y, Ge J, Shao Y, Ma P, Chen X and Lei B. Development of silica grafted poly(1,8-octanediolco-citrates) hybrid elastomers with highly tunable mechanical properties and biocompatibility. 2015. J. Mater. Chem. B. DOI: 10.1039/C4TB02089H

42. Dai Z#, Shao Y, Wang X, Xu D, Kang H, Min W, Lin S, Wang M, Kang A. Five common functional polymorphisms in microRNAs (rs2910164, rs2292832, rs11614913, rs3746444, rs895819) and the susceptibility of Breast Cancer: Evidence from 8361 cases and 8504 controls. 2015. Curr. Pharm. Des. 21(11):1455-63.

43. Dai Z#, Shao Y, Ma X, Xu D, Tang W, Kang H, Lin S, Wang M, Ren H, Wang X. Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer: An Updated Meta-Analysis Involving 34,590 Subjects. 2014. Dis Markers. doi: 10.1155/2014/484729.

44. Dai Z#, Kang H, Wang X, Shao Y, Lin S, Zhao Y, Ren H, Min W, Wang M, Liu X. Association between genetic polymorphisms in AURKA (rs2273535 and rs1047972) and breast cancer risk: a meta-analysis involving 37,221 subjects. 2014. Cancer Cell Int. 14(1):91. doi: 10.1186/s12935-014-0091-y.

45. Xue Y, Wang L, Shao Y, Yan J, Chen X, Lei B#. Facile and green fabrication of biomimetic gelatin-siloxane hybrid hydrogel with highly elastic properties for biomedical applications. 2014. Chem Eng J. 251:158-164.

46. Hartsough E, Shao Y, Aplin AE#. Resistance to RAF Inhibitors Revisited. 2014. J Invest Dermatol. 134:319-25.

47. Kaplan FM, Kugel C, Dadpey N, Shao Y, Abel EV, Aplin AE#. SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. 2012. J Biol Chem. 287:41797-807.

48. Kannoly S, Shao Y, Wang IN#. Genomic sequences and characterizations of two R-plasmid-dependent single-stranded RNA bacteriophages, C-1 and Hgal1: rethinking the evolution of ssRNA phages. 2012. J. Bacteriol. 194:5073-9.

49. Aplin AE#, Kaplan FM, Shao Y. Mechanisms of resistance to B-RAF inhibitors in melanoma. 2011. J Invest Dermatol. 131(9):1817-20.

50. Kaplan FM, Shao Y, Mayberry MM, Aplin AE#. Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells. 2011. Oncogene. 30(3):366-71.

51. Gallet R, Shao Y, Wang IN#. High adsorption rate is detrimental to bacteriophage fitness in a biofilm-like environment. 2009. BMC Evol Biol. 9:241.

52. Feldman L.S, Shao Y, Meinhold D, Miller C, Colon W, Osuna R#. 2006. Common and variable contributions of Fis residues to high-affinity binding at different DNA sequences. J. Bacteriol. 188:2081-2095.

53. Meinhold D, Beach M, Shao Y, Osuna R, Colon W#. The location of an engineered inter-subunit disulfide bond in FIS affects the denaturation pathway and cooperativity. 2006. Biochemistry. 45:9767-9777.