Yan Zheng

Zheng Yan

Email: zenyan66@126.com

ResearchGate: https://www.researchgate.net/profile/Yan-Zheng-76

Scopus Author Profile: https://www.scopus.com/authid/detail.uri?authorId=55251013300

Research Interests:

1) Scientific research: pathogenesis of psoriasis and skin cancers

2) Clinical aspects: treatment of psoriasis and urticarial with combination of Chinese and western medicine; pathological diagnosis of rare skin diseases; laser cosmetic treatment of skin

Experience:

2016-Present Department of dermatology, Xi’an Jiaotong University, Xi’an, China, Professor

2011-2016 Department of dermatology, Xi’an Jiaotong University, Xi’an, China, Associate Professor

2005-2007 Department of dermatology, Juntendo University, Japan, Postdoc

2003-2011 Department of dermatology, Xi’an Jiaotong University, Xi’an, China, Lecturer

Education:

1998-2003 Xi’an Jiaotong University Health Science Center, Xi’an, China, Ph.D.

1993-1998 Former Xi'an Medical University, Xi’an, China, B. M.

Honor & Awards:

1) Entry to the Ministry of Education New Century Excellent Talents Plan

2) Shaanxi Science and Technology Award, first prize and second prize

3) Science and Technology Award of Education Department of Shaanxi Province

4) Excellent Young and Middle-aged Doctor Award of Chinese Medical Doctors Association

5) Young Talent award of Xi’an Jiaotong University

About the Teaching:

Up to now, I have recruited more than 50 master and doctoral students, and have a mature and complete scientific research and teaching team.

Under my guidance, doctoral students won the title of outstanding doctoral dissertation and outstanding graduates of Xi'an Jiaotong University, two doctors obtained the National Natural Science Foundation of China, and one doctor obtained the qualification of the China Scholarship Council to study abroad.

1) Obtained the title of "Famous Teacher" by the Medical Department of Xi'an Jiaotong University.

2) Participated in compiling 7 books.

3) Published more than ten teaching papers.

4) Won the title of Excellent Teacher and Excellent Graduate Tutor.

About the clinical:

Focus on the treatment of psoriasis and urticarial with combination of Chinese and western medicine; pathological diagnosis of rare skin diseases; laser cosmetic treatment of skin.

1) The annual average number of outpatients is 10,000, more than 6,000 cases of skin difficult pathology are reported each year, and many rare cases are reported in clinical SCI papers.

2) Established a specialized clinic for psoriasis and urticaria.

About the scientific research:

Focus on the pathogenesis of psoriasis and skin tumors.

1) Presided over 13 national and provincial funds, including 7 National Natural Science Foundation of China projects and 5 provincial key projects.

2) Published more than 100 academic papers, including 60 SCI papers. A single SCI paper has been cited up to 167 times, and has been cited by the world's leading journal (Nature Review Immunology with an IF of 41), and one paper (JID: 7.1) has been selected as an ESI highly cited paper.

Representative Publications:

1) Han S, Yan Y, Ren Y, Hu Y, Wang Y, Chen L, Zhi Z, Zheng Y*, Shao Y*, Liu J*. LncRNA SAMMSON Mediates Adaptive Resistance to RAF Inhibition in BRAF-Mutant Melanoma Cells. CANCER RES, 81: 2918-2929, 2021. (IF: 12.70)

2) Wang M, Wang Y, Zhang M, Duan Q, Chen C, Su Q, Liu M, Zheng Y*, Shao, Y*, Kynureninase Contributes to the Pathogenesis of Psoriasis through Pro-Inflammatory Effect. J CELL PHYSIOL, 2021. (IF: 6.38)

3) Huang Y, Wang Y, Wang Y, Wang N, Duan Q, Wang S, Liu M, Bilal MA, Zheng Y*, LPCAT1 Promotes Cutaneous Squamous Cell Carcinoma via EGFR-Mediated Protein Kinase B/p38MAPK Signaling Pathways. The Journal of investigative dermatology, 2021. (IF: 8.55)

4) Wang X, Zhang Q, Li C, Qu X, Yang P, Jia J, Song L, Fan W, Jing H, Zheng Y*, Fibulin-3 Has Anti-Tumorigenic Activities in Cutaneous Squamous Cell Carcinoma. The Journal of investigative dermatology, 139, 2019. (IF: 8.55)

5) Li C, Xia L, Jia J, Li F, Wang X, Duan Q, Jing H, Yang P, Chen C, Wang Q, Liu J, Shao Y, Wang N, Zheng Y*, Cornulin is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways. The Journal of investigative dermatology, 139: 71-80, 2019. (IF: 8.55)

6) Han S, Ren Y, He W, Liu H, Zhi Z, Zhu X, Yang T, Rong Y, Ma B, Purwin TJ, Ouyang Z, Li C, Wang X, Wang X, Yang, H, Zheng Y, Aplin AE, Liu J, Shao Y, ERK-mediated Phosphorylation Regulates SOX10 Sumoylation and Targets Expression in Mutant BRAF Melanoma. NAT COMMUN, 9: 28, 2018. (IF: 14.91)

7) Jia J, Li C, Luo S, Liu-Smith F, Yang J, Wang X, Wang N, Lai B, Lei T, Wang Q, Xiao S, Shao Y*, Zheng Y*, Yes-Associated Protein Contributes to the Development of Human Cutaneous Squamous Cell Carcinoma via Activation of RAS. The Journal of investigative dermatology, 136: 1267-1277, 2016. (IF: 8.55)

8) Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu X, Zheng Y, Shen N, Chin YE, Wang H*, NF-κB-induced microRNA-31 Promotes Epidermal Hyperplasia by Repressing Protein Phosphatase 6 in Psoriasis. NAT COMMUN, 6: 7652, 2015. (IF: 14.91)

9) Qu X, Shen L, Zheng Y*, Cui Y, Feng Z, Liu F, Liu J, A Signal Transduction Pathway From TGF-β1 to SKP2 Via Akt1 and c-Myc and its Correlation with Progression in Human Melanoma. The Journal of investigative dermatology, 134: 159-167, 2014. (IF: 8.55)

10) Zheng Y, Niyonsaba F*, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H, Microbicidal Protein Psoriasin is a Multifunctional Modulator of Neutrophil Activation. IMMUNOLOGY, 124: 357-367, 2008. (IF: 7.39)

11) Zheng Y, Niyonsaba F*, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogaw H, Cathelicidin LL-37 Induces the Generation of Reactive Oxygen Species and Release of Human Alpha-Defensins From Neutrophils. The British journal of dermatology, 157: 1124-1131, 2007. (IF: 9.30)

Patents:

1) Application of Cornulin as target in preparation of drug for preventing and treating psoriasis. ZL201611269693.X Invention 2019.12.27

2) Application of Fibulin-3 taken as target point to prepare medicine for preventing and treating psoriasis. ZL201710917538.2 Invention 2019.12.27

3) Application of RIPK3 (Receptor-Interacting Protein Kinase 3) to preparation of drugs for preventing and treating psoriasis. 201811438480.4 Invention 2021.3.26