Songmei Geng

Curriculum Vitae 

Songmei Geng M.D., Ph.D.

Director, Department of Dermatology,

Second Hospital Affiliated to Xi’an Jiaotong University,

157 Xi Wu Road, Xi’an, Shaanxi Province, P.R. China, 710004

Tel 86-130-6042-3612 E-mail: gengsongmei73@163.com

Education and training

2015-2016 Department of Pathology, BWH, Harvard University, U.S. Visiting scholar

2003-2005 Department of Dermatology, Columbia University, U.S. Research training

2001-2006 Xi’an Jiaotong University, China, Ph.D.

1996-1999 Xi’an Medical University, China, M.S

1991-1996 Xi’an Medical University, China, M.D.

Faculty Appointments

2014- The Second Hospital Affiliated to Xi’an Jiaotong University, Professor

2008-2014 The Second Hospital Affiliated to Xi’an Jiaotong University, Associate Professor

2001-2008 The Second Hospital Affiliated to Xi’an Jiaotong University, Attending Doctor

1999-2001 The Second Hospital Affiliated to Xi’an Jiaotong University, Residency

Honors and Awards

2020 Honorable Doctor of Xi’an Jiaotong University

2019 Honorable Teacher of Xi’an Jiaotong University

2010 New Century Excellent Talents in University of Ministry of Education of China

2010 Awards for Excellent youth Dermatologists of China (CDA)

2010 Youth Science and Technology Award of Shaanxi Province

Funding Support

2022-2025 Innovation Group Research Program of Shaanxi Province(2022TD-48)

2021-2024 National Science Foundation of China (NSFC) (No. 82073451)

2020-2023 Shaanxi Provincial Key R&D Program- Joint Project of Universities (2020GXLH-Y-022)

2020-2021 Shaanxi Provincial Key R&D Program- Social Development Field 2020SF-175

2018-2022 Innovation Project of Ministry of Education (PY3A0241001016)

Completed Research

2014-2017 National Science Foundation of China (NSFC) (No. 81372912)

2012-2015 National Science Foundation of China (NSFC) (No. 81171490)

2010-2013 New Century Excellent Talents in University of Ministry of Education

( NCET- 10-0673)

2007-2010 National Scientific Foundation of China (NSFC) (No. 30600536)

Professional Activities:

President of the Dermatology Branch of the Chinese Doctor Association(CDA)of Shaanxi Province

Director of Rare Genetic Diseases Committee， Dermatology Branch of Chinese Doctor Association

Vice-Chairman of Dermatology Committee of China Rare Disease Alliance

Vice-Chairman of Dermatology and Skin Aging Prevention of the Chinese Geriatrics Society

Vice-President of the Chinese Gerontology Dermatology Branch

Standing Committee Member of the Dermatology Branch of the Chinese Medical Association

Standing Committee Member of the Research Hospital Dermatology Committee

Standing Committee Member of the Chinese Society of Rehabilitation Medicine Dermatology

Member of Chinese Preventive Medicine Dermatology Branch

Vice-Chairman of Shaanxi Branch of Chinese Medical Association Laser Medicine

Vice-Chairman of Dermatology Branch of Xi'an Medical Association

Deputy Editor-in-Chief, Chinese Journal of Dermatology and Venereology

Editorial Board Member of Journal of Clinical Dermatology

Editorial Board Member of International Journal of Dermatology and Venereology

Professional profile

In clinical work, I specialize in the treatment of severe and rare skin diseases and have found new genetic mutation loci in Blau syndrome, progeria, etc. I reported the first case of skin stiffness syndrome in China and successfully treat multiple warty xanthomas of the vulva with imiquimod, which was firstly published in JAAD. I have presented as a speaker at the East Asian Dermatology Congress (2012, 2014, 2018), Asian Dermatology Congress (2013), and World Dermatology Congress (2014, 2019). Our research results have been published in JEADV, JAAD, BJD, and other international academic journals.

My research fields include skin barrier, cutaneous tumor, psoriasis, and atopic dermatitis. Our group identified the effect of retinoic acid on the epidermal barrier and could affect TET2/5-hmc function. Aberrant TET2/5-hmc methylation regulation is involved in the development, progression, and drug resistance of cutaneous lymphoma, cutaneous squamous cell carcinoma, and melanoma. Meanwhile, our research team focuses on the mechanisms of pruritus and immune activation in chronic inflammatory skin diseases such as psoriasis and atopic dermatitis. Through clinical data analysis and the establishment of animal models, we found that dermatitis induced by retinoic acid, tacrolimus, and imiquimod is related to the activation of mast cell MRGPRX2 receptors. Further, we found pruritus in psoriasis and atopic dermatitis is mainly mediated by chronic non-histamine pathway, which laid the preliminary foundation for the further research of this project. To investigate the mechanism of the microenvironment in skin diseases, we collaborate with multidiscipline and look forward to promising outcomes in the future.